Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
68.63
-3.27 (-4.55%)
Apr 28, 2026, 4:00 PM EDT - Market closed
Spyre Therapeutics Analyst Ratings
Total Analysts
12
Consensus Rating
Strong Buy
Price Target
$85.08
Upside
+23.97%
Ratings History
| Analyst | Firm | Rating | Rating | Action | Price Target | Upside | Date |
|---|---|---|---|---|---|---|---|
| Jones Trading | Jones Trading | Strong Buy Maintains $64 → $95 | Strong Buy | Maintains | $64 → $95 | +38.42% | Apr 17, 2026 |
| Wells Fargo | Wells Fargo | Buy Maintains $50 → $90 | Buy | Maintains | $50 → $90 | +31.14% | Apr 14, 2026 |
| Wedbush | Wedbush | Buy Maintains $65 → $80 | Buy | Maintains | $65 → $80 | +16.57% | Apr 14, 2026 |
| Baird | Baird | Buy Maintains $65 → $90 | Buy | Maintains | $65 → $90 | +31.14% | Apr 14, 2026 |
| Raymond James | Raymond James | Strong Buy Initiates $80 | Strong Buy | Initiates | $80 | +16.57% | Apr 14, 2026 |
| Deutsche Bank | Deutsche Bank | Strong Buy Maintains $55 → $88 | Strong Buy | Maintains | $55 → $88 | +28.22% | Apr 14, 2026 |
| Leerink Partners | Leerink Partners | Buy Maintains $49 → $106 | Buy | Maintains | $49 → $106 | +54.45% | Apr 13, 2026 |
| Jefferies | Jefferies | Strong Buy Maintains $47 → $85 | Strong Buy | Maintains | $47 → $85 | +23.85% | Apr 13, 2026 |
| BTIG | BTIG | Strong Buy Maintains $70 → $98 | Strong Buy | Maintains | $70 → $98 | +42.79% | Apr 13, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +2.00% | Mar 31, 2026 |
| Stifel | Stifel | Strong Buy Maintains $70 → $92 | Strong Buy | Maintains | $70 → $92 | +34.05% | Mar 18, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +2.00% | Mar 16, 2026 |
| Wells Fargo | Wells Fargo | Buy Maintains $40 → $50 | Buy | Maintains | $40 → $50 | -27.15% | Feb 20, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +2.00% | Feb 20, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +2.00% | Jan 16, 2026 |
| Mizuho | Mizuho | Buy Initiates $53 | Buy | Initiates | $53 | -22.77% | Dec 18, 2025 |
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Analyst Star Rankings
Our analyst star rankings are based on these four factors
- Success Rate
- The percentage of ratings that are profitable.
- Average Return
- The average percentage return within one year of the rating.
- Rating Count
- The more ratings the analyst has provided, the higher the score.
- Recency
- Ratings provided within the past year contribute to a higher score.